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Learn how anatabine can lower inflammation, lower thyroid antibodies involved in Hashimoto’s (auto immune disorder of the thyroid) and potentially help with other autoimmune diseases.
Anatabine is a Solanaceae plant family (Tomato, Tobacco, Egg-plant) alkaloid marketed in the US as a dietary supplement.
Anatabine has been shown to inhibit NF-κB and STAT3 phosphorylation in animal models of Alzheimer’s disease and multiple sclerosis, acting to reduce the production of pro-inflammatory cytokines and other markers of inflammation, and to reduce cell and tissue damage caused by overproduction of these molecules ( Paris D et al Eur J Pharmacol. 2013)
It has demonstrated anti-inflammatory effects in vivo and in vitro, and may be useful for musculoskeletal aches and pains.
In a 282 person survey 232 (82%) reported a benefit from anatabine supplementation for one or more joint pain conditions, most commonly the knee, wrists/hands/fingers, shoulder, and back, most often due to osteoarthritis or injury to the joint. Lanier et al Clinical medicine insights. Arthritis and musculoskeletal disorders 2013)
A 12 week study on humans with Hashimotos thyroiditis, anatabine-treated patients had a significant reduction in absolute serum TgAb levels (thyroid antibodies relative to those receiving placebo (P = .027). This was a >20% drop in TgAb levels in the anatabine than placebo group. The researches concluded that the dose of anatabine may have been too low, although the amount taken per day (0.17–0.25 mg/kg, so better results may be obtained from a higher dose. (Schmeltz, L et al The Journal of clinical endocrinology and metabolism 2014).
In animal model of autoimmune thyroiditis, anatabine decreased thyroidal IL-1β and IL-18 levels which are inflammatory cytokines and macrophage COX-2 which also rises in pro inflammatory states.
This compound show promise for aiding patients with Hashimotos as well as aiding other autoimmune disorders.
Anatabine is structurally similar to nicotine, non-toxic and binds to acetyl choline receptors, offering improvement in working memory and attention in a variety of pre-clinical and clinical studies, but without the addictive properties of nicotine.